Peninsula Medical School
Recent Submissions
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Review of Evidence on Implementation in Education
(Education Endowment FoundationLondon, 2024-04-24) -
Anti-stigma interventions in low-income and middle-income countries: a systematic review
(Elsevier BV, 2024-06)Background Stigma exacerbates power imbalances and societal disparities, significantly impacting diverse identities and health conditions, particularly for low and middle-income countries (LMICs). Though crucial for ... -
A pragmatic, multicentre, double-blind, placebo-controlled randomised trial to assess the safety, clinical and cost-effectiveness of mirtazapine and carbamazepine in people with Alzheimer’s disease and agitated behaviours: the HTA-SYMBAD trial
(National Institute for Health and Care ResearchEngland, 2023-10)Background: Agitation is common and impacts negatively on people with dementia and carers. Non-drug patient-centred care is first-line treatment, but we need other treatment when this fails. Current evidence is sparse on ... -
Implementation of large, multi-site hospital interventions: a realist evaluation of strategies for developing capability
(Springer Science and Business Media LLCEngland, 2024-03-06)Background This study presents guidelines for implementation distilled from the findings of a realist evaluation. The setting was local health districts in New South Wales, Australia that implemented three clinical ... -
The Mental Wellbeing of Child and Adolescent Mental Health Service (CAMHS) Workers in England: A Cross-Sectional Descriptive Study Reporting Levels of Burnout, Wellbeing and Job Satisfaction
(MDPI AGSwitzerland, 2024-02-07)In the UK, there has been a notable increase in referrals to specialist children’s mental health services. This, coupled with shortages of qualified staff, has raised concerns about the escalating occupational stress ... -
Pharmacokinetics of propofol in severely obese surgical patients
(WileyEngland, 2024-03-13)Background Existing PK models of propofol include sparse data from very obese patients. The aim of this study was to develop a PK model based on standardised surgical conditions and spanning from normal-weight up to, and ... -
A dominant-negative regulatory mechanism of SQSTM1 droplets-based autophagy
(Informa UK LimitedUnited States, 2022-04-03)SQSTM1/p62 is an autophagy receptor, forming droplets to sequester intracellular polyubiquitinated cargo and mediate its delivery for autophagic clearance. SQSTM1 droplets can function as platforms to allow the formation ... -
Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
(Elsevier BVUnited States, 2024-03-26)Autophagy and ribonucleoprotein granules, such as P-bodies (PBs) and stress granules, represent vital stress responses to maintain cellular homeostasis. SQSTM1/p62 phase-separated droplets are known to play critical roles ... -
Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care: Protocol for the UK-ROX trial
(SAGE PublicationsEngland, 2024)<jats:sec><jats:title>Background:</jats:title><jats:p> In the United Kingdom, around 184,000 adults are admitted to an intensive care unit (ICU) each year with over 30% receiving mechanical ventilation. Oxygen is the ... -
Ethnic Inequalities in Sentencing: Evidence from the Crown Court in England and Wales
(Oxford University Press (OUP), 2024)<jats:title>Abstract</jats:title> <jats:p>In recent years, there has been considerable policy and academic interest in the existence of ethnic inequalities in the Criminal Justice System. A large body of ...