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dc.contributor.authorHerzog, N
dc.contributor.authorHartmann, H
dc.contributor.authorJanssen, LK
dc.contributor.authorWaltmann, M
dc.contributor.authorFallon, SJ
dc.contributor.authorDeserno, L
dc.contributor.authorHorstmann, A
dc.date.accessioned2024-03-21T14:51:34Z
dc.date.available2024-03-21T14:51:34Z
dc.date.issued2024-04-01
dc.identifier.issn0195-6663
dc.identifier.issn1095-8304
dc.identifier.other107179
dc.identifier.urihttps://pearl.plymouth.ac.uk/handle/10026.1/22216
dc.description.abstract

Computational models and neurophysiological data propose that a ‘gating mechanism’ coordinates distractor-resistant maintenance and flexible updating of working memory contents: While maintenance of information is mainly implemented in the prefrontal cortex, updating of information is signaled by phasic increases in dopamine in the striatum. Previous literature demonstrates structural and functional alterations in these brain areas, as well as differential dopamine transmission among individuals with obesity, suggesting potential impairments in these processes. To test this hypothesis, we conducted an observational case-control fMRI study, dividing participants into groups with and without obesity based on their BMI. We probed maintenance and updating of working memory contents using a modified delayed match to sample task and investigated the effects of SNPs related to the dopaminergic system. While the task elicited the anticipated brain responses, our findings revealed no evidence for group differences in these two processes, neither at the neural level nor behaviorally. However, depending on Taq1A genotype, which affects dopamine receptor density in the striatum, participants with obesity performed worse on the task. In conclusion, this study does not support the existence of overall obesity-related differences in working memory gating. Instead, we propose that potentially subtle alterations may manifest specifically in individuals with a ‘vulnerable’ genotype.

dc.format.extent107179-107179
dc.format.mediumPrint-Electronic
dc.languageen
dc.publisherElsevier BV
dc.subjectDopamine
dc.subjectMaintenance
dc.subjectObesity
dc.subjectTaq1A
dc.subjectUpdating
dc.subjectWorking memory gating
dc.subjectHumans
dc.subjectMemory, Short-Term
dc.subjectDopamine
dc.subjectMagnetic Resonance Imaging
dc.subjectBrain Mapping
dc.subjectBrain
dc.subjectPrefrontal Cortex
dc.titleWorking memory gating in obesity: Insights from a case-control fMRI study
dc.typejournal-article
dc.typeObservational Study
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38145879
plymouth.volume195
plymouth.publisher-urlhttp://dx.doi.org/10.1016/j.appet.2023.107179
plymouth.publication-statusPublished
plymouth.journalAppetite
dc.identifier.doi10.1016/j.appet.2023.107179
plymouth.organisational-group|Plymouth
plymouth.organisational-group|Plymouth|Faculty of Health
plymouth.organisational-group|Plymouth|Faculty of Health|School of Psychology
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA
plymouth.organisational-group|Plymouth|Users by role
plymouth.organisational-group|Plymouth|Users by role|Current Academic staff
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA|UoA04 Psychology, Psychiatry and Neuroscience
plymouth.organisational-group|Plymouth|REF 2029 Researchers by UoA
plymouth.organisational-group|Plymouth|REF 2029 Researchers by UoA|UoA04 Psychology, Psychiatry and Neuroscience
dc.publisher.placeEngland
dcterms.dateAccepted2023-12-18
dc.date.updated2024-03-21T14:51:33Z
dc.rights.embargodate2025-12-22
dc.identifier.eissn1095-8304
rioxxterms.versionofrecord10.1016/j.appet.2023.107179


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