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dc.contributor.authorSilva, LP
dc.contributor.authorFrawley, D
dc.contributor.authorAssis, LJD
dc.contributor.authorTierney, C
dc.contributor.authorFleming, AB
dc.contributor.authorBayram, O
dc.contributor.authorGoldman, GH
dc.contributor.editorMitchell AP
dc.date.accessioned2024-02-27T13:32:05Z
dc.date.available2024-02-27T13:32:05Z
dc.date.issued2020-10-28
dc.identifier.issn2379-5042
dc.identifier.issn2379-5042
dc.identifier.otherARTN e00818-20
dc.identifier.urihttps://pearl.plymouth.ac.uk/handle/10026.1/22090
dc.description.abstract

<jats:p> <jats:named-content content-type="genus-species">Aspergillus fumigatus</jats:named-content> is an important human-pathogenic fungal species that is responsible for a high incidence of infections in immunocompromised individuals. <jats:named-content content-type="genus-species">A. fumigatus</jats:named-content> high-osmolarity glycerol (HOG) and cell wall integrity pathways are important for the adaptation to different forms of environmental adversity such as osmotic and oxidative stresses, nutrient limitations, high temperatures, and other chemical and mechanical stresses that may be produced by the host immune system and antifungal drugs. Little is known about how these pathways are activated in this fungal pathogen. Here, we characterize four <jats:named-content content-type="genus-species">A. fumigatus</jats:named-content> putative homologues that are important for the activation of the yeast HOG pathway. <jats:named-content content-type="genus-species">A. fumigatus</jats:named-content> SlnA <jats:sup>Sln1p</jats:sup> , ShoA <jats:sup>Sho1p</jats:sup> , MsbA <jats:sup>Msb2p</jats:sup> , and OpyA <jats:sup>Opy2p</jats:sup> are genetically interacting and are essential for the activation of the HOG and cell wall integrity pathways. Our results contribute to the understanding of <jats:named-content content-type="genus-species">A. fumigatus</jats:named-content> adaptation to the host environment. </jats:p>

dc.format.extente00818-e00820
dc.format.mediumElectronic
dc.languageen
dc.publisherAmerican Society for Microbiology
dc.subjectAspergillus fumigatus
dc.subjectputative receptors
dc.subjectosmotic and cell wall stresses
dc.subjecthigh-osmolarity glycerol (HOG)
dc.subjectcaspofungin
dc.titlePutative Membrane Receptors Contribute to Activation and Efficient Signaling of Mitogen-Activated Protein Kinase Cascades during Adaptation of Aspergillus fumigatus to Different Stressors and Carbon Sources
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/32938702
plymouth.issue5
plymouth.volume5
plymouth.publisher-urlhttp://dx.doi.org/10.1128/msphere.00818-20
plymouth.publication-statusPublished
plymouth.journalmSphere
dc.identifier.doi10.1128/msphere.00818-20
plymouth.organisational-group|Plymouth
plymouth.organisational-group|Plymouth|Faculty of Health
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA
plymouth.organisational-group|Plymouth|Users by role
plymouth.organisational-group|Plymouth|Users by role|Academics
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA|UoA01 Clinical Medicine
plymouth.organisational-group|Plymouth|Faculty of Health|Peninsula Medical School
plymouth.organisational-group|Plymouth|REF 2028 Researchers by UoA
plymouth.organisational-group|Plymouth|REF 2028 Researchers by UoA|UoA01 Clinical Medicine
dc.publisher.placeUnited States
dc.date.updated2024-02-27T13:32:03Z
dc.identifier.eissn2379-5042
dc.rights.embargoperiodforever
rioxxterms.versionofrecord10.1128/msphere.00818-20


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