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dc.contributor.authorPanda, S
dc.contributor.authorMohanty, N
dc.contributor.authorPanda, S
dc.contributor.authorMishra, L
dc.contributor.authorGopinath, D
dc.contributor.authorSahoo, A
dc.contributor.authorNagraj, SK
dc.contributor.authorLapinska, B
dc.date.accessioned2024-01-17T15:56:11Z
dc.date.available2024-01-17T15:56:11Z
dc.date.issued2022
dc.identifier.issn2072-6694
dc.identifier.issn2072-6694
dc.identifier.other1886
dc.identifier.urihttps://pearl.plymouth.ac.uk/handle/10026.1/21912
dc.description.abstract

This systematic review and meta-analysis aims to address whether age can be a determinant of overall survival (OS), disease-free survival (DFS), recurrence, distant metastasis (DM) and second primary (SP) in surgically treated oral and oropharyngeal squamous cell carcinoma (OOPSCC). A total of 4981 cases and 44254 controls from 25 comparative observational studies were included in the analysis. A significantly better OS (matched subgroup analysis: OR 1.64; 95% CI 1.31–2.04, overall analysis: OR 1.48; 95% CI 1.09–2.01) was observed in young patients compared to older adults, with heterogeneity ranging from moderate to severe. Worse DFS (unmatched subgroup analysis OR 0.43; 95% CI 0.27–0.68) was observed in young patients compared to older adults with minimal to moderate heterogeneity. The frequency of recurrence (OR 1.49; 95% CI 1.10–2.02) and DM (OR 1.83; 95% CI 1.10–3.03) was significantly higher in the young patients, as found in unmatched and matched subgroup analysis, with the least heterogeneities. Young age can be considered as an independent prognostic factor for recurrence and distant metastases in OOP-SCC. Larger and methodologically robust observational studies with longer follow-up are needed to establish the definitive role of age as an independent prognostic factor on OS and DFS in OOPSCC.

dc.format.extent1886-1886
dc.format.mediumElectronic
dc.languageen
dc.publisherMDPI AG
dc.subjectoral carcinoma
dc.subjectoverall survival
dc.subjectdisease-free survival
dc.subjectoropharyngeal squamous cell carcinoma
dc.subjectrecurrence
dc.subjectdistant metastasis
dc.subjectsecond primary
dc.subjectsystematic review
dc.titleAre Survival Outcomes Different for Young and Old Patients with Oral and Oropharyngeal Squamous Cell Carcinoma? A Systematic Review and Meta-Analysis
dc.typejournal-article
dc.typeReview
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35454794
plymouth.issue8
plymouth.volume14
plymouth.publisher-urlhttp://dx.doi.org/10.3390/cancers14081886
plymouth.publication-statusPublished online
plymouth.journalCancers
dc.identifier.doi10.3390/cancers14081886
plymouth.organisational-group|Plymouth
plymouth.organisational-group|Plymouth|Faculty of Health
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA
plymouth.organisational-group|Plymouth|Users by role
plymouth.organisational-group|Plymouth|Users by role|Academics
plymouth.organisational-group|Plymouth|Users by role|Post-Graduate Research Students
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA|UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group|Plymouth|Faculty of Health|Peninsula Dental School
plymouth.organisational-group|Plymouth|REF 2028 Researchers by UoA
plymouth.organisational-group|Plymouth|REF 2028 Researchers by UoA|UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
dc.publisher.placeSwitzerland
dcterms.dateAccepted2022-04-06
dc.date.updated2024-01-17T15:56:09Z
dc.rights.embargodate2024-1-19
dc.identifier.eissn2072-6694
dc.rights.embargoperiod
rioxxterms.versionofrecord10.3390/cancers14081886


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