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dc.contributor.authorKing, N
dc.contributor.authorDieberg, G
dc.contributor.authorSmart, NA
dc.date.accessioned2018-03-20T11:14:05Z
dc.date.available2018-03-20T11:14:05Z
dc.date.issued2016-09
dc.identifier.issn2405-5875
dc.identifier.issn2405-5875
dc.identifier.otherC
dc.identifier.urihttp://hdl.handle.net/10026.1/11114
dc.description.abstract

Objectives Trials of remote ischemic pre-conditioning (RIPC) have suggested this intervention reduces complications of percutaneous coronary intervention and coronary by-pass surgery. The aims of this work were to (i) conduct a systematic review and meta-analysis of the effects of RIPC on cardiac and renal damage in patients undertaking elective percutaneous coronary intervention (PCI); (ii) summarize the results in an evidence-based clinical context. Methods We conducted a systematic search of published randomized controlled trials of RIPC for elective PCI up until May 1st, 2015. Studies of peri- or post-ischemic conditioning or emergency PCI were excluded. Results Nine studies, totalling 1253 patients were included. Compared to control, RIPC groups exhibited reduced peri-procedural myocardial infarction (MI) Odds Ratio (OR) 0.72 (95% CI 0.54 to 0.97, p = 0.03); ST-segment deviation OR 0.42 (95% CI 0.28 to 0.63, p < 0.0001); major adverse cardiac events (MACE) OR 0.41 (95% CI 0.21 to 0.84, p = 0.01); and acute kidney injury (AKI) OR 0.47 (95% CI 0.26 to 0.86, p = 0.01), but not mortality OR 1.00 (95% CI 0.27 to 3.73, p = 1.00). Conclusions RIPC is likely to prevent major adverse cardiac and renal events in patients undertaking elective PCI.

dc.format.extent1-6
dc.languageen
dc.language.isoen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject32 Biomedical and Clinical Sciences
dc.subject3202 Clinical Sciences
dc.subject42 Health Sciences
dc.subjectHeart Disease - Coronary Heart Disease
dc.subjectHeart Disease
dc.subjectKidney Disease
dc.subjectCardiovascular
dc.subjectClinical Research
dc.subjectClinical Trials and Supportive Activities
dc.subjectCardiovascular
dc.titleEffects of pre-procedural remote ischaemic pre-conditioning on the outcomes of elective percutaneous coronary intervention. A systematic review and meta-analysis
dc.typejournal-article
dc.typeJournal Article
plymouth.volume21
plymouth.publisher-urlhttp://dx.doi.org/10.1016/j.ctrsc.2016.06.001
plymouth.publication-statusPublished
plymouth.journalClinical Trials and Regulatory Science in Cardiology
dc.identifier.doi10.1016/j.ctrsc.2016.06.001
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dcterms.dateAccepted2016-06-25
dc.identifier.eissn2405-5875
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1016/j.ctrsc.2016.06.001
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2016-09
rioxxterms.typeJournal Article/Review


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